OLIVE LEAF POLYPHENOLS LOADED MUCOADHESIVE ORAL FILMS

Among drug delivery systems, mouth dissolving films (MDFs) are a form of administration with many advantages. Some problems could be experienced, primarily in pediatric and geriatric patients conventional methods as swallowing. It is great convenience to dispensing the film dispersed such cases. In this study, for preparation films, solvent casting method was preferred. The effect biopolymer ratio loaded olive leaf extract on properties were investigated central composite experimental design. Characterization studies prepared done AFM, SEM, FTIR analysis. Based characterization studies, four best formulations chosen, further investigations focused these formulations. Formulation 8 chosen optimum formulation among 17 due its better flexibility homogeneity, lower disintegration time 200s, higher antioxidant capacity 3.21 mM TEAC/g MDF. obtained data revealed that it possible deliver polyphenols films.